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R1512 Sigma-Aldrich

Retinyl palmitate

potency: ≥1,700,000 USP units per g

Synonym: Vitamin A palmitate, all−trans−Retinol palmitate

  • CAS Number 79-81-2

  • Empirical Formula (Hill Notation) C36H60O2

  • Molecular Weight 524.86

  •  Beilstein/REAXYS Number 1917366

  •  EC Number 201-228-5

  •  MDL number MFCD00019414

  •  PubChem Substance ID 24899347

  •  NACRES NA.79

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Properties

Related Categories Biochemicals and Reagents, Vitamin A, Vitamins More...
biological source   synthetic (organic)
form   solid or viscous liquid
potency   ≥1,700,000 USP units per g
does not contain   antioxidant
color   yellow to yellow-green
mp   26 °C
storage temp.   2-8°C
SMILES string   CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
InChI   1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
InChI key   VYGQUTWHTHXGQB-FFHKNEKCSA-N

Description

General description

Retinyl palmitate or vitamin A palmitate is a retinoid, which is an acid form of vitamin A. Retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinyl palmitate is a major storage form of vitamin A found in epidermis. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed.

Application

Retinyl palmitate has been used as a standard in high performance liquid chromatography (HPLC). It has also been used to study its effect on brain regeneration in larval Xenopus laevis.

Packaging

5 g in ampule

Biochem/physiol Actions

Retinyl palmitate is widely used in pharmaceutical applications. It is also extensively used in cosmetic formulations due to its beneficial effects on the appearance of skin and anti-oxidant properties. Retinyl palmitate acts as a teratogen and affect vertebrate embryogenesis and regeneration. It is added as a source of vitamin A in low fat and skim milks. Retinyl palmitate acts as a chemopreventive or antineoplastic agent.

Review: Vitamin A metabolism.

Packaging

Sealed ampule.

Physical form

oil or solid

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
381.2 °F - closed cup
Flash Point(C) 
194 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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