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R2533 Sigma-Aldrich

RS-127445 hydrochloride

≥98% (HPLC), powder

Synonym: 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride

  • CAS Number 199864-86-3

  • Empirical Formula (Hill Notation) C17H16FN3 · HCl

  • Molecular Weight 317.79

  •  MDL number MFCD11112196

  •  PubChem Substance ID 329824019

  •  NACRES NA.77

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Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to tan
solubility   DMSO: ≥20 mg/mL
originator   Roche
storage temp.   2-8°C
SMILES string   Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
InChI   1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
InChI key   MKJPYBJBPRFMHL-UHFFFAOYSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Target organs 
Respiratory system
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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