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R7884 Sigma

Ribonuclease B from bovine pancreas

BioReagent, ≥50 Kunitz units/mg protein, ≥80% (SDS-PAGE)

Synonym: RNase B




100 mg in poly bottle

500 μg in poly bottle

Package size based on protein content

Preparation Note

Purified by affinity chromatography


Ribonuclease B from bovine pancreas is used in the digestion of RNA during cell cycle platform analysis.

Biochem/physiol Actions

Native RNase BS generated by subtilisin digestion of native RNase B comprising of amino acid residues 21-124 of RNase B, is sensitive to PNGase F digestion. Intramolecular N-glycans of bovine pancreatic RNase B function like chaperone. RNase B is found to be much faster than RNase A, while RNase A is liable to aggregate during regeneration. The stimulatory effect of Asn-oligosaccharide (which corresponds to the most predominant sugar chain of RNase B) reveals that the N-glycans of RNase B facilitates the transformation of bulky intermediates into folded, compact species.

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Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How should Ribonuclease B from bovine pancreas, Product R7884, be reconstituted?
This product may be reconstituted directly in water at a concentration of 1 mg/mL.
What is the extinction coefficient of Ribonuclease B from bovine pancreas (RNase B), Product R7884?
The E1% for this enzyme is 8.0 when measured at 280 nm.
What is the difference between RNase B, Ribonuclease B from bovine pancreas, Product R7884, and RNase A?
The amino acid sequence for the two enzymes is the same. The difference between them is that RNase B is a glycoprotein and contains 6 mannose residues and 2 residues of N-acetylglucosamine.
How do I find price and availability?
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
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