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R8404 Sigma-Aldrich

Rufinamide

≥98% (HPLC), powder

Synonym: 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide

  • CAS Number 106308-44-5

  • Empirical Formula (Hill Notation) C10H8F2N4O

  • Molecular Weight 238.19

  •  MDL number MFCD00865314

  •  PubChem Substance ID 24724595

  •  NACRES NA.77

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Properties

Related Categories Anticonvulsants, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white
solubility   DMSO: 9 mg/mL
originator   Novartis
storage temp.   −20°C
SMILES string   NC(=O)c1cn(Cc2c(F)cccc2F)nn1
InChI   1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-3,5H,4H2,(H2,13,17)
InChI key   POGQSBRIGCQNEG-UHFFFAOYSA-N
Gene Information   human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

Application

Rufinamide has been used to test its analgesic effect on neuropathic pain in spared nerve injury (SNI) model.

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Rufinamide may elicit inhibition of the sodium channels and block action potential generation. This property makes it an antiepileptic drug for treating epilepsy disorders like Lennox-Gastaut syndrome.

Broad-spectrum anticonvulsant.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Diagnostic Implications

Effective therapy for partial seizures in adults and childhood seizures in Lennox-Gastaut syndrome.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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