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R9281 Sigma-Aldrich

Rotigotine hydrochloride

≥98% (HPLC)

Synonym: (−)-(S)-5,6,7,8-Tetrahydro-6-(propyl(2-(2-thienyl)ethyl)amino)-1-naphthol hydrochloride, (−)-N 0437, N 0923, Neupro, SPM 962

  • CAS Number 125572-93-2

  • Empirical Formula (Hill Notation) C19H25NOS·HCl

  • Molecular Weight 351.93

  •  MDL number MFCD00906149

  •  PubChem Substance ID 329824046

  •  NACRES NA.77

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Properties

Related Categories Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
color   white to off-white
solubility   DMSO: >10 mg/mL
originator   UCB Inc.
storage temp.   room temp
SMILES string   Cl.CCCN(CCc1cccs1)[C@H]2CCc3c(O)cccc3C2
InChI   1S/C19H25NOS.ClH/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21;/h3-7,13,16,21H,2,8-12,14H2,1H3;1H/t16-;/m0./s1
InChI key   CEXBONHIOKGWNU-NTISSMGPSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Rotigotine hydrochloride is a non-ergolinic D3/D2 and D1-dopamine agonist. It is appropriate for transdermal delivery through skin patches, that has the drug in a silicone-based adhesive matrix.

Rotigotine is a dopamine receptor agonist with preference for D3 receptors over D2 and D1. As such, it is an effective anti-Parkinsonian agent. Racemic rotigotine is about 50 times as potent as quinpirole, the gold standard D2 agonist.

Features and Benefits

This compound was developed by UCB Inc.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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