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RAB1271 Sigma-Aldrich

Human Arginase 1 ELISA

for serum, plasma and cell culture supernatants

  •  NACRES NA.32

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Properties

Related Categories Antibodies, Antibody Kits, ELISA Kits, Sandwich ELISAs
species reactivity   human
packaging   kit of 96 wells (12 strips x 8 wells)
application(s)   ELISA: suitable
input   sample type plasma
sample type serum
sample type cell culture supernatant(s)
assay range   inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2.05 ng/mL
standard curve range: 2.048-500 ng/mL
detection method   colorimetric
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... ARG1(383)

Description

General description

The gene encoding arginase 1 (ARG1), spanning 10-15kb on genomic DNA, is localized on human chromosome 6q23.2. It consists of eight exons. The protein consists of 322 amino acids and is expressed in the liver, red blood cells, lactating mammalian glands and the kidney.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem/physiol Actions

Arginase 1 (ARG1) is a liver enzyme involved in the hydrolysis of arginine to form ornithine and urea. In addition to urea cycle, ARG1 is also implicated in various cellular processes, such as macrophage-mediated cytotoxicity and regulation of immune response. The encoded protein is also involved in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury. Deficiency or mutations in the gene leads to a rare urea cycle disorder, argininemia.

Other Notes

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Warning
Hazard statements 
RIDADR 
UN 3264 8 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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