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RES0113M-A7 SAFC

MES monohydrate

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym: 2-(N-Morpholino)ethanesulfonic acid, 4-Morpholineethanesulfonic acid monohydrate

  • CAS Number 145224-94-8

  • Empirical Formula (Hill Notation) C6H13NO4S · H2O

  • Molecular Weight 213.25

  •  Beilstein/REAXYS Number 6350956

  •  EC Number 224-632-3

  •  MDL number MFCD00149409

  •  PubChem Substance ID 329824236

  •  NACRES NA.21

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Properties

Related Categories Biochemicals and Reagents, Biological Buffers, Good’s Buffers, PharmaGrade Buffers
Quality Level   400
biological source   synthetic
Agency/Method   non-compendial
product line   PharmaGrade
form   powder
application(s)   cell culture | mammalian: suitable
impurities   Endotoxin, microbial, and trace metals, tested
useful pH range   5.5 - 6.7
pKa (25 °C)   6.1
mp   >300 °C (lit.)
suitability   suitable for manufacturing use
foreign activity   Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
SMILES string   O.OS(=O)(=O)CCN1CCOCC1
InChI   1S/C6H13NO4S.H2O/c8-12(9,10)6-3-7-1-4-11-5-2-7;/h1-6H2,(H,8,9,10);1H2
InChI key   MIIIXQJBDGSIKL-UHFFFAOYSA-N

Description

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Application

MES is a biological buffer often referred to as a “Good’s” buffer .The pKa of MES is 5.96 which makes MES an ideal candidate for cell culture media and protein based buffer formulations to maintain a stable environment in solution. MES is considered to be non-toxic to culture cell lines, highly water soluble and provides high solution clarity.

MES is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream), and diagnostic reagents. MES based buffers are used in purification bioprocesses of antibodies, peptides, proteins, blood components and growth factors.

Packaging

Product is available in the following package sizes:
RES0113M-A701X: 100g container
RES0113M-A703X: 5kg container
RES0113M-A705X: 25kg container
RES0113M-A706X: 50kg container

Linkage

Enhanced Quality Product Documentation on PharmaGrade MES monohydrate

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

pHast Pack
Protocols & Articles

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Peer-Reviewed Papers
15

References

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