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RES0703P-A7 Sigma

PIPES

PharmaGrade, Manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production, suitable for cell culture

Synonym: 1,4-Piperazinediethanesulfonic acid, PIPES, Piperazine-1,4-bis(2-ethanesulfonic acid), Piperazine-N,N′-bis(2-ethanesulfonic acid)

  • CAS Number 5625-37-6

  • Empirical Formula (Hill Notation) C8H18N2O6S2

  • Molecular Weight 302.37

  •  Beilstein Registry Number 817713

  •  EC Number 227-057-6

  •  MDL number MFCD00006159

  •  PubChem Substance ID 329824241

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Properties

Related Categories Biochemicals and Reagents, Biological Buffers, Good’s Buffers, PharmaGrade Buffers
Quality Level   ELITE
biological source   synthetic
grade   Non-Compendial
InChI Key   IHPYMWDTONKSCO-UHFFFAOYSA-N
product line   PharmaGrade
assay   ≥99.0%
form   powder
impurities   Endotoxin and microbial; tested
useful pH range   6.1 - 7.5
pKa (25 °C)   6.8
mp   >300 °C(lit.)
solubility   1 M NaOH: 5%, clear, colorless
suitability   suitable for cell culture
  suitable for manufacturing use
foreign activity   Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

Description

Application

PIPES is a biological buffer often referred to as a “Good’s” buffer. The pKa of PIPES is 6.8 which makes it ideal for biological applications at physiological conditions. PIPES is considered to be non-toxic to culture cell lines and provides high-solution clarity at the typical buffer pH.

PIPES can be used in a wide array of biological applications, including as a component in media formulations. Specific applications include buffers for cell culture and diagnostic reagent production.

General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.

Linkage

Enhanced Quality Product Documentation on PharmaGrade PIPES

Packaging

Product is available in the following package sizes:
RES0703P-A701X: 100 gm container
RES0703P-A702X: 1 kg container
RES0703P-A704X: 10 kg container

Safety & Documentation

High Quality GMP-Buffers

Protein Stabilizer
Protocols & Articles

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Peer-Reviewed Papers
15

References

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