S0130 Sigma-Aldrich


≥75% α-anomer basis, ≥98% (HPLC), powder

Synonym: N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozotocin

  • CAS Number 18883-66-4

  • Empirical Formula (Hill Notation) C8H15N3O7

  • Molecular Weight 265.22

  •  Beilstein/REAXYS Number 2060675

  •  EC Number 242-646-8

  •  MDL number MFCD00006607

  •  PubChem Substance ID 57654595

  •  NACRES NA.77



Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action,
Quality Level   200
assay   ≥75% α-anomer basis
  ≥98% (HPLC)
form   powder
color   white to light yellow
mp   121 °C (dec.) (lit.)
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   neoplastics
originator   Pfizer
storage temp.   −20°C
SMILES string   CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI   1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1


General description

Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.


Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research.


1, 5 g in glass bottle

50, 100, 500 mg in glass bottle

Biochem/physiol Actions

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

Clinically, the chemical is used for the treatment of pancreatic β cell carcinoma.

Features and Benefits

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Mixed anomers

Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
Precautionary statements 
UN 3077 9 / PGIII
WGK Germany 


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How should I store Product S0130, Streptozocin, upon receipt?
Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.
How do I store solutions of Product S0130, Streptozocin?
Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.
What is the half-life of Product S0130, Streptozocin?
Streptozocin has a reported half life of 15 to 30 minutes.
How can I make a solution of Product S0130, Streptozocin?
This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.
CanProduct S0130, Streptozocin, be used to induce diabetes? What concentration should be used?
We do not test Streptozocin, Product No. S0130 for biological activity.We recommend screening lots for biological activity.An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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