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S0323 Sigma-Aldrich

Sematilide monohydrochloride monohydrate

≥98% (HPLC), powder

Synonym: CK-1752A, N-[2-(Diethylamino)ethyl]-4′-[(methylsulfonyl)amino]benzamide monohydrochloride monohydrate

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
InChI Key   HCGUEOOYHHAYIM-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to beige
solubility   H2O: 2 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

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Protocols & Articles

Articles

Potassium Channels

Potassium channels are essential in both excitable and non-excitable cells for the control of membrane potential, regulation of cell volume, and the secretion of salt, neurotransmitters and hormones....
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Peer-Reviewed Papers
15

References

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