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S0447 Sigma-Aldrich

SIS3

≥98% (HPLC), powder

Synonym: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

  • CAS Number 521984-48-5

  • Empirical Formula (Hill Notation) C28H27N3O3 · HCl

  • Molecular Weight 489.99

  •  MDL number MFCD09265258

  •  PubChem Substance ID 24724599

  •  NACRES NA.77

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Description

Application

Sugar insensitive 3 (SIS3) has been used as smad3 inhibitor in various cells.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.

SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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