EMAIL THIS PAGE TO A FRIEND
S0758 Sigma-Aldrich

Sulfaphenazole

≥98%

Synonym: 4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide

  • CAS Number 526-08-9

  • Empirical Formula (Hill Notation) C15H14N4O2S

  • Molecular Weight 314.36

  •  EC Number 208-384-3

  •  MDL number MFCD00057226

  •  PubChem Substance ID 24278198

  •  NACRES NA.77

Purchase

Properties

Related Categories A to C, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
Quality Level   100
assay   ≥98%
form   powder
solubility   ethanol: 25 mg/mL, clear, colorless to yellow
storage temp.   2-8°C
SMILES string   Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3
InChI   1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
InChI key   QWCJHSGMANYXCW-UHFFFAOYSA-N
Gene Information   human ... CYP2C18(1562), CYP2C19(1557), CYP2C9(1559)

Description

Application

Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition. It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells and microsomal preparations.

Packaging

1 g in poly bottle

Biochem/physiol Actions

Antibacterial. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Inhibits bradykinin-induced tPA release.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
DA9520000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?