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S0885 Sigma-Aldrich

Somatostatin

powder, γ-irradiated, BioXtra, suitable for cell culture

Synonym: Growth hormone release inhibiting factor, SRIF, Somatostatin-14, Somatotropin release inhibiting factor

  • CAS Number 38916-34-6

  • Empirical Formula (Hill Notation) C76H104N18O19S2

  • Molecular Weight 1637.88

  •  Beilstein/REAXYS Number 6436064

  •  EC Number 254-186-5

  •  MDL number MFCD00076762

  •  PubChem Substance ID 24899450

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, GPCR Modulators,
InChI Key   NHXLMOGPVYXJNR-FQSIDJEASA-N
sterility   γ-irradiated
product line   BioXtra
form   powder
potency   0.3-50 ng/mL
solubility   cell culture medium: 10 mL/vial
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   human ... SSTR1(6751), SSTR2(6752), SSTR3(6753), SSTR4(6754), SSTR5(6755)

Description

Amino Acid Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Biochem/physiol Actions

Somatostatin regulates endocrine function and cell proliferation via interaction with G-protein-coupled somatostatin receptors. It exists in two active forms produced by alternative cleavage of a single preproprotein (14 aa and 28 aa forms). Somatosatin inhibits the release of growth hormone; thyroid-stimulating hormone and a range of gastrointestinal hormones: Cholecystokinin (CCK); Enteroglucagon; Gastrin; Gastric inhibitory polypeptide (GIP); Motilin; Secretin; Vasoactive intestinal peptide (VIP).

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 2 μg/ml stock solution, add 10 ml sterile culture medium.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
WF8751700

Documents

Certificate of Analysis

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Certificate of Origin

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Making Headway
Protocols & Articles

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Peer-Reviewed Papers
15

References

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