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S1014 Sigma-Aldrich

Streptonigrin from Streptomyces flocculus

≥98%

Synonym: Bruneomycin, Nigrin

  • CAS Number 3930-19-6

  • Empirical Formula (Hill Notation) C25H22N4O8

  • Molecular Weight 506.46

  •  Beilstein/REAXYS Number 599390

  •  EC Number 223-501-8

  •  MDL number MFCD00063401

  •  PubChem Substance ID 24899458

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Description

Biochem/physiol Actions

Streptonigrin (SN) is an aminoquinone antitumour antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by SN are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
RTECS 
TJ7350000

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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