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  • S1190 - Anti-SLIPR/MAGI-3 antibody produced in rabbit

S1190 Sigma-Aldrich

Anti-SLIPR/MAGI-3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   indirect immunofluorescence: 2.0 μg/mL using 293T cells transfected with recombinant Slipr.
  microarray: suitable
  western blot (chemiluminescent): 1.0 μg/mL using extracts of 293T cells transfected with recombinant Slipr
species reactivity   rat
mol wt   antigen 140-160 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   Q9JK71
Gene Information   rat ... Magi3(245903)


General description

MAGI-3 possesses a guanylate-kinase-like region, six PDZ and two WW domains. This gene is located on human chromosome 1p13.

The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons, and are believed to be involved in the assembly of multiprotein complexes via their protein-protein interaction domains.2

MAGI-3 (also termed SLIPR) was identified in a two hybrid screening as a protein interacting with the tumor suppressor PTEN,6 and Receptor Tyrosine Phosphatase β (RPTPβ).7


Staining by immunoblotting and immunofluorescence is specifically inhibited by the immunizing peptide.


synthetic peptide corresponding to amino acids 835-850 of SLIPR (rat homolog of MAGI-3) conjugated to KLH via a N-terminal added lysine residue.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide as a preservative.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Membrane associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3) serves as a scaffold protein for frizzled-4 and Ltap . It helps to control the c-Jun N-terminal kinase (JNK) signaling cascade.

Safety & Documentation

Safety Information

WGK Germany 
Protocols & Articles


Antibodies to MAGI-1, MAGI-2, MAGI-3/SLIPR

The MAGUK (Membrane Associated Guanylate kinase) family of proteins, whose prototypic member is PS95, is characterized by the presence of multi-PDZ and SH3 domains, and a single region of homology to...
Keywords: Adhesion, Western blot

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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