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S1763 Sigma

Somatostatin

powder, BioReagent, suitable for cell culture

Synonym: Growth hormone release inhibiting factor, SRIF, Somatostatin-14, Somatotropin release inhibiting factor

  • CAS Number 38916-34-6

  • Empirical Formula (Hill Notation) C76H104N18O19S2

  • Molecular Weight 1637.88

  •  Beilstein/REAXYS Number 6436064

  •  EC Number 254-186-5

  •  MDL number MFCD00076762

  •  PubChem Substance ID 24899493

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Properties

Related Categories Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Hormones, Neuropeptides,
InChI Key   NHXLMOGPVYXJNR-FQSIDJEASA-N
product line   BioReagent
assay   ≥97% (HPLC)
form   powder
solubility   H2O: 1 mg/mL
suitability   suitable for cell culture
storage temp.   −20°C
Gene Information   human ... SSTR1(6751), SSTR2(6752), SSTR3(6753), SSTR4(6754), SSTR5(6755)

Description

Amino Acid Sequence

Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys

Application

Somatostatin has been used in cell culture. It has also been used in the study of glucose-6-phosphate dehydrogenase activity in monolayer cultures of thyroid epithelial cells.

Biochem/physiol Actions

Somatostatin regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
Somatostatin (SST) is a peptide. It performs several functions like anti-proliferation, pro-apoptosis and anti-migration. Somatostatin performs physiological activities with the help of various G protein-coupled receptor subtypes (SST receptor (SSTR)-1, SSTR2A, SSTR2B, and SSTR3–5).

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Reconstitution

To prepare 2 μg/ml stock solution, dissolve in 5 ml sterile culture medium per μg somatostatin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
WF8751700

Documents

Certificate of Analysis

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Certificate of Origin

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Request a Serum Sample

Cell Culture Guide
Protocols & Articles

Articles

HPLC Analysis of Peptide Mixture on Zenix® SEC-100

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Peptide Mixture on Zenix® SEC-100
Keywords: Chromatography, High performance liquid chromatography, Size-exclusion chromatography

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Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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