• USA Home
  • S2188 - γ-Secretase inhibitor

EMAIL THIS PAGE TO A FRIEND
S2188 Sigma-Aldrich

γ-Secretase inhibitor

≥90% (TLC), powder

  • CAS Number 200810-93-1

  • Empirical Formula (Hill Notation) C33H57F2N5O9

  • Molecular Weight 705.83

Purchase

Description

Application

γ-Secretase inhibitor was used to inhibit proteolytic processing of the transmembrane receptor, p75NTR in CNS myelin extract from rats and megalin COOH-terminal fragment in opossum kidney proximal tubule cells.

Biochem/physiol Actions

γ-Secretase activity is essential for the cleavage of β-amyloid precursor protein and the generation of amyloid β-peptide. γ-Secretase inhibitor are effective in preventing the accumulation of amyloid β-peptide in Alzheimer′s disease patients. It also inhibits the proteolytic processing of Notch protein and may be effective in treatment of colorectal neoplastic disease.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin


Meet Synthia - Retrosynthesis Sofware

Making Headway
Protocols & Articles

Articles

Cancer Stem Cells: New Targets for Cancer Therapy

Interested in receiving more content like this? Join over 8,000 of your peers who have already signed up for the Cell Informer newsletter.
Keywords: Cancer, Cell attachment, Cell culture, Cell proliferation, Gastrointestinal, Gene expression, Transcription, transformation

Non-Small Cell Lung Cancer (NSCLC)

Non-small cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC). NSCLC accounts for about 85% of all lung cancers. It is a disease in which mal...
Keywords: Antitumor agents, Apoptosis, Cancer, Clinical, Diagnostic, Diseases, Enzyme-linked immunosorbent assay, High performance liquid chromatography, Ligands, Oncology, Thin layer chromatography

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?