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S2626 Sigma

Spermidine

≥99% (GC)

Synonym: 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

  • CAS Number 124-20-9

  • Linear Formula NH2(CH2)3NH(CH2)4NH2

  • Molecular Weight 145.25

  •  Beilstein Registry Number 1698591

  •  EC Number 204-689-0

  •  MDL number MFCD00008229

  •  PubChem Substance ID 24899529

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
InChI Key   ATHGHQPFGPMSJY-UHFFFAOYSA-N
assay   ≥99% (GC)
form   solid or liquid (clear)
refractive index   n20/D 1.479(lit.)
density   0.925 g/mL at 25 °C(lit.)
storage temp.   room temp
Gene Information   rat ... Ppm1a(24666)

Description

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Other Notes

Store under inert gas. Air sensitive; strongly hygroscopic.

Packaging

1, 5, 25 g in glass bottle

Application

Spermidine has been used:
• in the preparation of 5x transcription buffer
• in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
• as a standard in the analytical study of rat brain polyamines (185)

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

General description

The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3259PSN2 8 / PGII
WGK Germany 
3
RTECS 
EJ7000000
Flash Point(F) 
233.6 °F
Flash Point(C) 
112 °C

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
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What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Is this a spermidine solution or a neat liquid, and what is the concentration?
Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.
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Protocols & Articles

Articles

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide
Keywords: Chromatography, Clinical, Derivatizations, High performance liquid chromatography

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers
15

References

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740780 Spermidine-(butyl-13C4) trihydrochloride, 99 atom % 13C, 95% (CP)

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