S2626 Sigma-Aldrich


≥99% (GC)

Synonym: 1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

  • CAS Number 124-20-9

  • Linear Formula NH2(CH2)3NH(CH2)4NH2

  • Molecular Weight 145.25

  •  Beilstein/REAXYS Number 1698591

  •  EC Number 204-689-0

  •  MDL number MFCD00008229

  •  PubChem Substance ID 24899529

  •  NACRES NA.32



Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
Quality Level   200
biological source   synthetic
assay   ≥99% (GC)
form   solid or liquid (clear)
impurities   DNase, none detected
  RNase, none detected
  protease, none detected
refractive index   n20/D 1.479 (lit.)
mp   22-25 °C
solubility   water: 50 mg/mL, clear to very slightly hazy, colorless to very faintly yellow
density   0.925 g/mL at 25 °C (lit.)
storage temp.   room temp
InChI   1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
Gene Information   rat ... Ppm1a(24666)


General description

The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.


Spermidine has been used:
• in the preparation of 5x transcription buffer
• in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
• as a standard in the analytical study of rat brain polyamines (185)


1, 5, 25 g in glass bottle

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.


Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Other Notes

Store under inert gas. Air sensitive; strongly hygroscopic.

Safety & Documentation

Safety Information

GHS05  GHS05
Signal word 
Hazard statements 
UN 3259PSN2 8 / PGII
WGK Germany 
Flash Point(F) 
233.6 °F - closed cup
Flash Point(C) 
112 °C - closed cup


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Is this a spermidine solution or a neat liquid, and what is the concentration?
Based on a density of 0.925 g/mL and a molecular weight of 145.25, this neat liquid has an effective molarity of 6.4 M.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
Show more questions
Protocols & Articles


HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide
Keywords: Chromatography, Clinical, Derivatizations, High performance liquid chromatography

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

709891 Spermidine-(butyl-d8) trihydrochloride, 98 atom % D, 95% (CP)
740780 Spermidine-(butyl-13C4) trihydrochloride, 99 atom % 13C, 95% (CP)

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?