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S3007 Sigma-Aldrich

Sodium salicylate

ReagentPlus®, ≥99.5%

Synonym: 2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate

  • CAS Number 54-21-7

  • Linear Formula HOC6H4COONa

  • Molecular Weight 160.10

  •  Beilstein/REAXYS Number 3732792

  •  EC Number 200-198-0

  •  MDL number MFCD00002440

  •  PubChem Substance ID 24899540

  •  NACRES NA.25

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Properties

Related Categories Aromatic Compounds, Cell Biology, Nutrition Research, Phytochemicals by Chemical Classification
Quality Level   200
product line   ReagentPlus®
assay   ≥99.5%
mp   >300 °C (lit.)
SMILES string   [Na+].Oc1ccccc1C([O-])=O
InChI   1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
InChI key   ABBQHOQBGMUPJH-UHFFFAOYSA-M

Description

General description

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.

Application

Sodium salicylate has been used:
• to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.
• to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.
• to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.

Packaging

1 kg in poly bottle

5 kg in poly drum

500 g in poly bottle

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
VO5075000
Flash Point(F) 
208.9 °F - Pensky-Martens closed cup
Flash Point(C) 
98.3 °C - Pensky-Martens closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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