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S3319 Sigma-Aldrich

sPLA2 inhibitor

Synonym: 5-(4-Benzyloxyphenyl)-4S-(7-phenylheptanoylamino)pentanoic acid, KH064

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Enzyme Inhibitors,
Quality Level   100
assay   ≥97.5% (HPLC)
form   powder
storage condition   under inert gas
color   white
mp   133-135 °C
solubility   DMSO: 20 mg/mL, clear
storage temp.   2-8°C
SMILES string   OC(=O)CC[C@@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CCCCCCc3ccccc3
InChI   1S/C31H37NO4/c33-30(16-10-2-1-5-11-25-12-6-3-7-13-25)32-28(19-22-31(34)35)23-26-17-20-29(21-18-26)36-24-27-14-8-4-9-15-27/h3-4,6-9,12-15,17-18,20-21,28H,1-2,5,10-11,16,19,22-24H2,(H,32,33)(H,34,35)/t28-/m0/s1
InChI key   KWLUIYFCMHKLKY-NDEPHWFRSA-N

Description

Application

sPLA2 inhibitor has been used in:
•  human lung adenocarcinoma cells in matrigel invasion assay
•  pre-treatment of cultured oligodendrocytes
• the inhibition of secretory phospholipase A2 in lung adenocarcinoma.

sPLA2 inhibitor was used to study the effects on cell proliferation and apoptosis of lung cancer cells and oligodendrocytes.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Secretory phospholipase A2 inhibitor blocks the activation of NF-κB, Akt, p38 MAPK and ERK pathways. It reduces proliferation and induces apoptosis of lung cancer cells and is a potent anti-inflammatory agent. sPLA2 inhibitor prevents deposition of collagen and has anti-fibrotic effects in hypertensive rats.

sPLA2 inhibitor is lipophilic and corresponds to a molecular weight of 487.63 Da. It regulates inflammatory responses and lipoprotein function and may be useful in treating atherosclerosis.

sPLA2 inhibitor (pla2g2a) is an orally active, potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor. Secretory phospholipase A2 inhibitor blocks the activation of NF-KB, Akt, p38 MAPK and ERK pathways. sPLA2 inhibitor reduces proliferation and induces apoptosis of lung cancer cells and is a potent anti-inflammatory agent. sPLA2 inhibitor prevents deposition of collagen and has anti-fibrotic effects in hypertensive rats.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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