S3626 Sigma-Aldrich


≥98%, liquid

Synonym: 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene

  • CAS Number 111-02-4

  • Linear Formula [(CH3)2C[=CHCH2CH2C(CH3)]2=CHCH2-]2

  • Molecular Weight 410.72

  •  Beilstein/REAXYS Number 1728919

  •  EC Number 203-826-1

  •  MDL number MFCD00008912

  •  PubChem Substance ID 24899564

  •  NACRES NA.25



Related Categories Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Culture, Chemopreventive Agents,
Quality Level   100
assay   ≥98%
form   liquid
color   light yellow
refractive index   n20/D 1.494 (lit.)
bp   285 °C/25 mmHg (lit.)
mp   −75 °C (lit.)
density   0.858 g/mL at 25 °C (lit.)
storage temp.   2-8°C
InChI   1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+


General description

Squalene is a hydrocarbon containing double bond commonly found in shark liver oil. It is also present in vegetable oils but to a lesser extent.


Squalene has been used:
• as a standard for lipid identification and quantification
• in the isolation of macrophages for parasite incubation
• as a standard for the quantification of squalene in squalene analysis of oil samples


1 L in glass bottle

10, 100, 500 mL in glass bottle

Biochem/physiol Actions

Squalene is a biosynthetic precursor to all steroids. It acts as a cytoprotective agent to normal cells exposed to carcinogens and antitumor agents. Squalene helps in equalizing the blood cholesterol levels. It increases the production of HDL (high density lipoprotein) and the excretion of LDL (low density lipoprotein). This helps in reducing the risk of heart disease and protects the less stable body fats from oxidation. It is also used in treating hypercholesterolemia. Squalene is known to improve the efficiency of cholesterol lowering drugs. It also serves as an antioxidant by preventing the effects of free radical. It protects skin from drying and other environmental conditions such as oxidation, ultraviolet rays and pollutants. Squalene is known to promote wound healing.

Safety & Documentation

Safety Information

GHS08  GHS08
Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Cholesterol Biosynthesis

Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the t...
BioFiles 2007, 2.7, 3.
Keywords: Catalysis, Decarboxylations, Metabolic Pathways, Oxidations, PAGE, Phosphorylations, Reductions

Choosing the optimal vaccine adjuvant

The word "vaccination" was first coined by English scientist Edward Jenner in 1796, although early forms of vaccination have been documented as far back as the 17th century.1 Vaccination is used to g...
BioFiles Vol. 5, No. 3
Keywords: Cancer, Clinical, Diseases, Inflammation, Veterinary

Dietary Terpenes

Terpenes comprise the largest and most diverse class of secondary metabolites; approximately 55,000 compounds have been identified to date.1 While the enzymes responsible for terpene synthesis are fo...
BioFiles 2008, 3.9, 4.
Keywords: Anti-inflammatory agents, Antimicrobials, Antiparasitics, Apoptosis, Building blocks, Cancer, Carcinogens, Cell division, Condensations, Detergents, Gene expression, Hormones, Insecticides, Isomerizations, Metabolites, Neurotransmitters, Poisons, Pollination, Reproduction, Vitamins

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

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Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
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Peer-Reviewed Papers


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