EMAIL THIS PAGE TO A FRIEND
S3944 Sigma-Aldrich

SEW2871

≥98% (HPLC), solid

Synonym: 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole

  • CAS Number 256414-75-2

  • Empirical Formula (Hill Notation) C20H10F6N2OS

  • Molecular Weight 440.36

  •  MDL number MFCD00096600

  •  PubChem Substance ID 24724607

  •  NACRES NA.77

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Lipids in Cell Signaling,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
storage condition   protect from light
color   white
mp   94.5-95.3 °C
solubility   DMSO: ≥10 mg/mL
  H2O: insoluble
storage temp.   2-8°C
SMILES string   FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F
InChI   1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H
InChI key   OYMNPJXKQVTQTR-UHFFFAOYSA-N
Gene Information   human ... S1PR1(1901), S1PR2(9294), S1PR3(1903), S1PR4(8698), S1PR5(53637)

Description

Application

SEW2871 has been used as a sphingosine-1 phosphate (S1P) receptor agonist to determine the effects of reconstituting plasma apolipoprotein M (ApoM) /S1P on vascular permeability in mice.

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation. SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration. By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.

Novel, selective human sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Light sensitive.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number
Protocols & Articles
Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?