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S5816 Sigma-Aldrich

Stromal Cell-Derived Factor 1α/pre-B Cell Growth Stimulating Factor from mouse

SDF-1α, recombinant, expressed in E. coli, powder, cell culture tested

Synonym: SDF-1α/PBSF



Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines, Cytokines and Growth Factors,
biological source   mouse
recombinant   expressed in E. coli
assay   >97% (SDS-PAGE)
form   powder
potency   0.15-0.6 ng/mL ED50
quality   endotoxin tested
mol wt   predicted mol wt ~8 kDa
packaging   pkg of 10 μg
storage condition   avoid repeated freeze/thaw cycles
impurities   <1 EU/μgtested (LAL test)
suitability   cell culture tested
UniProt accession no.   P40224
storage temp.   −20°C
Gene Information   mouse ... Cxcl12(20315)


Analysis Note

The biological activity is measured by its ability to chemoattract cultured human lymphocytes and mouse BaF3 cells transfected with human CXCR4.

Preparation Note

Recombinant Mouse Stromal Cell-Derived Factor 1α (SDF-1α)/Pre-B Cell Growth Stimulating Factor (PBSF) is produced from a DNA sequence encoding the mature mouse SDF-1α protein sequence (amino acid residues 22-89) expressed in Escherichia coli. Recombinant mouse SDF-1α (68 amino acids) has a predicted molecular mass of approximately 8 kDa.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.


Stromal Cell-Derived Factor 1α/pre-B Cell Growth Stimulating Factor from mouse has been used in invasion assay. It has also been used to study the SDF-1 release from chitosan-based nanoparticles.

Biochem/physiol Actions

SDF-1α/PBSF, a member of the α (CXC) chemokine family, is a chemoattractant for T lymphocytes and monocytes, but not neutrophils. SDF-1α/PBSF is highly conserved between species, with only one amino acid substitution between the human and mouse proteins. SDF-1α and SDF-1β (together also known as SDF-1α/PBSF) are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the C-terminal of SDF-1β and absent from SDF-1α..

Stromal derived factor-1 (SDF-1) is an insulin-desensitizing factor, upregulated during both starvation and obesity. Exogenic SDF-1 reduces insulin-mediated signaling and glucose uptake. SDF-1 mediates migration of cortical interneurons and endothelial progenitor cells of the bone marrow through chemotaxis.

General description

Stromal derived factor-1 (SDF-1) is localized to adipocytes.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Request a Serum Sample

Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers


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S8406 Stromal Cell-Derived Factor 1β/pre-B Cell Growth Stimulating Factor human, >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested

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