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S6444 Sigma-Aldrich

N-Salicyloyltryptamine

≥98% (HPLC), solid

Synonym: 2-Hydroxy-N-[2-(1H-indol-3-yl)ethyl]benzamide, STP

  • CAS Number 31384-98-2

  • Empirical Formula (Hill Notation) C17H16N2O2

  • Molecular Weight 280.32

  •  MDL number MFCD06798353

  •  PubChem Substance ID 329824563

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
color   white
solubility   DMSO: ~26 mg/mL
storage temp.   2-8°C
SMILES string   Oc1ccccc1C(=O)NCCc2c[nH]c3ccccc23
InChI   1S/C17H16N2O2/c20-16-8-4-2-6-14(16)17(21)18-10-9-12-11-19-15-7-3-1-5-13(12)15/h1-8,11,19-20H,9-10H2,(H,18,21)
InChI key   XBPYTDZHCNJRBY-UHFFFAOYSA-N

Description

Biochem/physiol Actions

N-Salicyloyltryptamine (STP) is a central nervous system depressant that inhibits the transient outward and sustained K+ current in neuroendocrine cells. This decreases the ability of neuronal cells to generate action potential.1,3 STP is has immunomodulatory effects as it inhibits the activation of ERK 1/2 and NF-κB.4

Activator of calcium-activated K+ channels; anticonvulsant and neuroprotectant.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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