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S7900 Sigma-Aldrich

Saponin from quillaja bark

Sapogenin content ≥10 %

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Description

General description

Saponins are natural steroidal glycoside (terpenes).

Application

Saponin from Quillaja bark has been used:
• to stain CD4+ and CD8+ T-cells
• to lyse trophozoite-infected red blood cells
• in immunohistochemical staining

Packaging

25, 100 g in poly bottle

Biochem/physiol Actions

Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Hence it is used as vaccine adjuvants. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects.

Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.

Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
VQ1400000

Documents

Certificate of Analysis

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Certificate of Origin

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Pipette Controller from Brand

Cell Culture Guide
Protocols & Articles

Articles

Choosing the optimal vaccine adjuvant

The word "vaccination" was first coined by English scientist Edward Jenner in 1796, although early forms of vaccination have been documented as far back as the 17th century.1 Vaccination is used to g...
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Keywords: Cancer, Clinical, Diseases, Inflammation, Veterinary

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Peer-Reviewed Papers
15

References

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