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S8260 Sigma-Aldrich

Salbutamol

Synonym: α-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-α,α′-diol, Albuterol

  • CAS Number 18559-94-9

  • Empirical Formula (Hill Notation) C13H21NO3

  • Molecular Weight 239.31

  •  Beilstein/REAXYS Number 6405698

  •  EC Number 242-424-0

  •  MDL number MFCD00148978

  •  PubChem Substance ID 24278712

  •  NACRES NA.77

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Properties

Related Categories Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index,
Quality Level   100
solubility   methanol: complete 50 mg/ml, clear, colorless to yellow
originator   GlaxoSmithKline
SMILES string   CC(C)(C)NCC(O)c1ccc(O)c(CO)c1
InChI   1S/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3
InChI key   NDAUXUAQIAJITI-UHFFFAOYSA-N
Gene Information   human ... ADRB2(154)

Description

Application

Salbutamol was administered to primate model to study the bronchoconstriction in chronic allergic asthma.20 Salbutamol was used as a standard for rapid pharmacokinetic screening of human plasma samples using HPLC.21

Packaging

100, 250 mg in poly bottle

25, 50 mg in glass insert

Biochem/physiol Actions

Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2

β2-adrenoceptor agonist

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
ZE4400000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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