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S8627 Sigma-Aldrich

Sulfacetamide

≥98.0%

Synonym: N-(4-Aminobenzenesulfonyl)acetamide, N-(4-Aminophenylsulfonyl)acetamide, N1-Acetylsulfanilamide

  • CAS Number 144-80-9

  • Empirical Formula (Hill Notation) C8H10N2O3S

  • Molecular Weight 214.24

  •  Beilstein/REAXYS Number 981718

  •  EC Number 205-640-6

  •  MDL number MFCD00066501

  •  PubChem Substance ID 24899803

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents, Chemical Structure Class,
InChI Key   SKIVFJLNDNKQPD-UHFFFAOYSA-N
assay   ≥98.0%
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  mycoplasma

Description

General description

Chemical structure: sulfonamide

Application

Sulfacetamide is an antibiotic that is used to treat skin infections and urinary tract infections. Sulfacetamide is used to study the treatment of acne and seborrheic dermatitis. It is used to study neonatal chlamydial conjunctivitis and meningococcal conjunctivitis.

Biochem/physiol Actions

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Packaging

100G,500G

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
AC8450000

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles
Peer-Reviewed Papers
15

References

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