EMAIL THIS PAGE TO A FRIEND
S9066 Sigma-Aldrich

SKF-89976A

>98% (HPLC), solid

Synonym: 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride

  • CAS Number 85375-15-1

  • Empirical Formula (Hill Notation) C22H25NO2 · HCl

  • Molecular Weight 371.90

  •  MDL number MFCD01321071

  •  PubChem Substance ID 24278796

  •  NACRES NA.77

Purchase

Properties

Related Categories Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
Quality Level   100
assay   >98% (HPLC)
form   solid
color   white
solubility   DMSO: soluble 20 mg/mL
  H2O: insoluble
originator   GlaxoSmithKline
storage temp.   2-8°C
SMILES string   Cl[H].OC(=O)C1CCCN(CC\C=C(/c2ccccc2)c3ccccc3)C1
InChI   1S/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H
InChI key   SNGGBKYQZVAQKA-UHFFFAOYSA-N
Gene Information   human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Slc6a1(79212), Slc6a12(50676)

Description

Application

SKF-89976A was used to study the role of adenosine receptors in uptake of GABA transport.4,5

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

SKF-89976A contains a cyclic amino acid with lipophilic moiety that enables the compound to cross the blood-brain barrier.1,2 It decreases the excitotoxic swelling of chick retina cells by blocking the glutamate-induced GABA release.3

GABA transporter type 1 (GAT-1) inhibitor that crosses the blood brain barrier.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?