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S9632 Sigma-Aldrich

Sulconazole nitrate salt

Synonym: 1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole

  • CAS Number 61318-91-0

  • Empirical Formula (Hill Notation) C18H15Cl3N2S · HNO3

  • Molecular Weight 460.76

  •  MDL number MFCD00058163

  •  PubChem Substance ID 24899846

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents,
form   powder
color   white
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
storage temp.   room temp
SMILES string   O[N+]([O-])=O.Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1
InChI   1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
InChI key   CRKGMGQUHDNAPB-UHFFFAOYSA-N

Description

General description

Chemical structure: imidazole

Application

Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases.

Biochem/physiol Actions

Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
NI4475000
Protocols & Articles

Articles

HPLC Analysis of Sulconazole Enantiomers on Astec® Cellulose DMP

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Sulconazole Enantiomers on Astec® Cellulose DMP
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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