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  • SAB1300308 - Anti-GPC4 (N-term) antibody produced in rabbit

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SAB1300308 Sigma-Aldrich

Anti-GPC4 (N-term) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Synonym: Anti-GPC4, Anti-Glypican-4, Anti-K-glypican, Anti-Secreted glypican-4

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, GP-GP, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: 1:50-1:100
  indirect ELISA: 1:1000
species reactivity   human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   saturated ammonium sulfate (SAS) precipitated
antibody product type   primary antibodies
NCBI accession no.   NP_001439
UniProt accession no.   O75487
Gene Information   human ... GPC4(2239)

Description

General description

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3′ end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.

GPC4 (glypican-4) gene is mapped to human chromosome Xq26.2. The encoded protein is a heparan sulfate proteoglycan and localizes to membrane microdomains.

Immunogen

GPC4 (NP_001439, 30-66)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human GPC4.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Biochem/physiol Actions

GPC4 (glypican-4) is associated with a number of signaling mechanisms involving growth factors. GPC4 influences cell proliferation, by serving as a co-receptor for growth factors. It regulates the Wnt signaling pathway. GPC4 might be associated with epileptic seizures, with this gene upregulated in the brain. GPC4 is an adipokine and is known to enhance insulin signaling and regulate adipocyte differentiation. Overexpression of this gene in polycystic ovary syndrome might be associated with the risk of cardiovascular disease.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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