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  • SAB1300331 - Anti-MLLT2 (N-term) antibody produced in rabbit

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SAB1300331 Sigma-Aldrich

Anti-MLLT2 (N-term) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Synonym: Anti-2, Anti-ALL1 FUSED GENE FROM CHROMOSOME 4, Anti-MIXED LINEAGE LEUKEMIA, Anti-TRANSLOCATED TO

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, MF-MN, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   indirect ELISA: 1:1000
species reactivity   human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   saturated ammonium sulfate (SAS) precipitated
Quality Level   100
antibody product type   primary antibodies
NCBI accession no.   NP_005926
UniProt accession no.   P51825
Gene Information   human ... MLLT2(4299)

Description

General description

MLLT2 is involved in acute leukemias through a chromosomal translocation t(4;11)(q21;q23) that involves mllt2 and mll/hrx. AF-4 (MLLT2), AF-9, and ENL proteins contain nuclear targeting sequences as well as serine-rich and proline-rich regions. Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains. AF4 is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus. The composition of the complete MLL-AF4 fusion product argues that it may act through either a gain-of-function or a dominant negative mechanism in leukemogenesis.

Immunogen

MLLT2 (NP_005926, 6-38)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MLLT2.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
nwg
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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