• USA Home
  • SAB1304932 - ANTI-NUP88 (C-TERM) antibody produced in rabbit

EMAIL THIS PAGE TO A FRIEND
SAB1304932 Sigma-Aldrich

ANTI-NUP88 (C-TERM) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: NUP88, Nuclear pore complex protein Nup88

Purchase

Properties

conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 1:1000
species reactivity   human
mol wt   83542 Da
form   buffered aqueous solution
shipped in   wet ice
storage temp.   −20°C
antibody form   IgG fraction of antiserum
antibody product type   primary antibodies
NCBI accession no.   NP_002523.2
UniProt accession no.   Q99567

Description

General description

NUP88 (Nucleoporin 88kDa) is an 88kDa non-FG nucleoporin. It acts as a component of a novel nuclear pore complex (NPC). It consists of a C-terminal coiled-coil domain and an interaction domain. It is localized in the cytoplasmic surface of nuclear pore complexes (NPCs). NUP88 consists of two domains, N-terminal and C-terminal domains and its N-terminal and C-terminal domains have been predicted to form β-propeller and a coiled-coil domain.

Application

ANTI-NUP88 (C-TERM) antibody produced in rabbit is suitable for western blot analysis at a dilution of 1:250-1:500.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

NUP88 (Nucleoporin 88kDa) participates in trafficking between the nucleus and cytoplasm. Its N-terminal β-propeller domain interacts with the FG (phenylalanine-glycine) repeat domain of nucleoporin CAN/Nup214. Further, it binds directly to CRM-1/exportin-1, the receptor for export of most proteins from the nucleus. Nup88 also possesses the ability to bind to the other FG nucleoporins Nup358 and Nup98. Overexpression of NUP88 has been observed in several types of malignancies such as colorectal cancer (CRC) and breast cancer cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

???PDP_SDS_LOT_NUMBER_ERROR_MSG???
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

Related Content

Antibody Explorer | Buy Primary Antibodies & Secondary Antibodies

Primary, Secondary and Recombinant Monoclonal Antibodies Providing highly cited primary and secondary antibodies, we have you covered for your ELISA, western blot, immunohistochemistry or other assay...
Keywords: Alzheimer Disease, Cancer, Chromatin immunoprecipitation, Diagnostic, Enzyme-linked immunosorbent assay, Flow cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Neuroscience, Western blot

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?