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SAB1400707 Sigma

Anti-PDZD3 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym: Anti-FLJ22756, Anti-IKEPP, Anti-PDZK2



Related Categories Alphabetical Index, Antibodies, PD-PG, Primary Antibodies
species reactivity   human
application(s)   western blot: 1 μg/mL
clone   polyclonal
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PDZD3(79849)
biological source   rabbit
conjugate   unconjugated



PDZD3 (NP_079067.2, 1 a.a. ~ 491 a.a) full-length human protein.


General description

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM

Physical form

Solution in phosphate buffered saline, pH 7.4

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Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
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