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  • SAB1405214 - Monoclonal Anti-XPO5 antibody produced in mouse

SAB1405214 Sigma-Aldrich

Monoclonal Anti-XPO5 antibody produced in mouse

clone 2C5-1B3, ascites fluid

Synonym: FLJ14239, FLJ32057, FLJ45606, KIAA1291



Related Categories Alphabetical Index, Antibodies, Primary Antibodies, X
conjugate   unconjugated
clone   2C5-1B3, monoclonal
biological source   mouse
application(s)   indirect ELISA: suitable
  western blot: 1:500-1:1000
species reactivity   human
mol wt   antigen ~56.91 kDa
shipped in   dry ice
storage temp.   −20°C
antibody form   ascites fluid
isotype   IgG1κ
antibody product type   primary antibodies
NCBI accession no.   BC000129
UniProt accession no.   Q9HAV4
Gene Information   human ... XPO5(57510)


General description

Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM


XPO5 (AAH00129, 1 a.a. ~ 280 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.


Physical form

Clear solution

Biochem/physiol Actions

XPO5 (exportin 5) is responsible for the translocation of miRNA (micro-RNA) precursor from nucleus to cytoplasm. Studies in HeLa cells show that miR-138 lowers the stability of XPO5 protein, thus, decreasing miRNA processing. This protein is also involved in the transport of short hairpin (shRNA). It docks on the nuclear pore complex and transports three classes of RNAs, tRNA, Y-RNA and miRNA precursors, across the nuclear membrane, in a RanGTP-RanGDP gradient-dependent manner.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers


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