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SAB2500059 Sigma-Aldrich

Anti-ALDH1A1 (Internal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ALDC, Anti-ALDH-E1, Anti-ALDH1, Anti-Aldehyde dehydrogenase 1 family member A1

  •  NACRES NA.41

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Properties

Related Categories AL-AL, Alphabetical Index, Antibodies, Primary Antibodies
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   indirect ELISA: suitable
  western blot: suitable
species reactivity   human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
UniProt accession no.   P00352
Gene Information   human ... ALDH1A1(216)

Description

General description

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) gene with 13 exons, extending over 52kb on genomic DNA, is mapped to human chromosome 9q21.13. ALDH1A1 is a tetrameric protein with 501 amino acids. It is expressed in variety of tissues, including the central nervous system (CNS) and liver. The encoded protein belongs to the ALDH superfamily.

Immunogen

Peptide with sequence C-RELGEYGFHEYTE from the internal region of the protein sequence according to NP_000680.2.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Aldehyde dehydrogenase 1 family member A1 (ALDH1A1) plays a vital role in acetaldehyde and neurotransmitter metabolism. It also facilitates the secretion of retinoic acid that is necessary for gene expression and tissue differentiation, as well as in cyclophosphamide detoxification. Studies show that ALDH1A1 variant is associated with the risk of developing alcohol dependence and other alcohol-use disorders, alcohol-induced flushing and sensitivity to alcohol. In addition, variations in the gene also leads to cataract formation. ALDH1A1 can also be used as a stem cell marker for various cancers.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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