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SAB2500096 Sigma-Aldrich

Anti-Arachidonate 5-lipoxygenase antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ALOX5, Anti-RP11-67C2.3

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Properties

Related Categories AR-AR, Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Lipids in Cell Signaling,
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   indirect ELISA: suitable
  western blot: suitable
species reactivity   human, canine, rat, mouse
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
UniProt accession no.   P09917
Gene Information   human ... ALOX5(240)

Description

General description

The gene ALOX5 (arachidonate 5-lipoxygenase), also referred to as 5-LOX (5-lipoxygenase), encodes a protein belonging to the lipoxygenase family. The gene is mapped to human chromosome 10q11.21. The protein contains a distinct ‘C2-like’ domain at the amino terminal that is involved in Ca2+-dependent membrane binding and a large catalytic domain containing the non-heme catalytic iron. It is highly unstable with short-lived activity.

Immunogen

Peptide with sequence C-ERNKKKQLPYYYLSPD from the C Terminus of the protein sequence according to NP_000689.1.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Biochem/physiol Actions

The gene ALOX5 (arachidonate 5-lipoxygenase) encodes a lipoxygenase that catalyzes the conversion of arachidonic acid (AA) and other fatty acids to bioactive compounds such as 5(S)-hydroxyeicosatetraenoic acid (5-HETE), leukotriene B4 (LTB4), and other leukotrienes. These leukotrienes and lipoxins function as mediators of inflammatory response. ALOX5 has been implicated in tumorigenesis and may serve as a potential therapeutic target and biomarker.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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