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SAB2501314 Sigma-Aldrich

Anti-SUMF1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-AAPA3037, Anti-FGE, Anti-MGC131853, Anti-MGC150436, sulfatase modifying factor 1

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Primary Antibodies, SU-SY
conjugate   unconjugated
clone   polyclonal
biological source   goat
application(s)   indirect ELISA: suitable
  western blot: suitable
species reactivity   human, rat, mouse
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
UniProt accession no.   Q8NBK3
Gene Information   human ... SUMF1(285362)

Description

General description

Sulfatase modifying factor 1 (SUMF1) or formylglycine-generating enzyme (FGE) is a 41kDa glycoprotein. It is localized at the lumen of the endoplasmic reticulum. The protein consists of an amino-terminal domain and a core domain with the active site. The gene encoding SUMF1 is localized on human chromosome 3p26.1 and contains nine exons.

Immunogen

Peptide with sequence CETLNPKGPPSGKDR, from the internal region of the protein sequence according to NP_877437.2.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Sulfatase modifying factor 1 (SUMF1) converts a highly conserved cysteine in the catalytic domain of sulfatase to form C α-formylglycine (FGly) by post-translational modification. Mutations in the gene encoding this protein have been associated with multiple sulfatase deficiency.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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