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  • SAB2900373 - Anti-PDCD1 (AB2) antibody produced in rabbit

SAB2900373 Sigma

Anti-PDCD1 (AB2) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution



Related Categories Alphabetical Index, Antibodies, PD-PG, Primary Antibodies
species reactivity   mouse, human
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
  western blot: suitable
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... PDCD1(5133)
biological source   rabbit
conjugate   unconjugated



Synthetic peptide from human PDCD1 / CD279.

General description

Programmed cell death protein 1 (PDCD1) is part of the cluster of differentiation 28 (CD28) superfamily. It interacts with its ligands, that is, programmed death ligand-1 and -2 (PD-L1/PD-L2). The gene encoding this protein is localized to human chromosome 2q37.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Biochem/physiol Actions

Programmed cell death protein 1 (PDCD1) plays an important role in the immune regulation by acting as a negative co-stimulatory factor. It suppresses the functions and multiplication of T cells, thereby reducing the release of IL-2 (interleukin-2), IL-10 and IFN-γ (interferon γ). In the presence of tumor microenvironment, PDCD1 along with its ligand modulates T effector functioning, thereby protecting cancer cells from immune-associated rejection. Mutation in this gene is associated with symptoms and progression of multiple sclerosis and susceptibility to systemic lupus erythematosus.

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Safety Information

RIDADR  NONH for all modes of transport
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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