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  • SAB3500070 - Anti-THEM2 antibody produced in rabbit

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SAB3500070 Sigma-Aldrich

Anti-THEM2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-ACOT13, Anti-Acyl-CoA thioesterase 13, Anti-PNAS-27, Anti-Thioesterase superfamily member 2

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, Primary Antibodies, T,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunofluorescence: suitable
  immunohistochemistry: suitable
  indirect ELISA: suitable
  western blot: suitable
species reactivity   rat, mouse, human
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
NCBI accession no.   NP_060943
UniProt accession no.   Q9NPJ3
Gene Information   human ... ACOT13(55856)

Description

General description

Acyl-CoA thioesterase 13 (ACOT13), also known as thioesterase superfamily member 2 (THEM-2), is encoded by the gene mapped to human chromosome 6p22.3. The encoded protein has a molecular mass of ∼15kDa with 140 amino acids. It is a member of the hotdog-domain thioesterase family. THEM2 is highly expressed in several tissues such as heart, kidney, liver and brown adipose tissue (BAT). It has been shown to be co-localized with β-tubulin on microtubules. At least two isoforms of THEM2 are known to exist.

Immunogen

THEM2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human THEM2.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Biochem/physiol Actions

Acyl-CoA thioesterase 13 (ACOT13)/thioesterase superfamily member 2 (THEM-2) possesses thioesterase activity, with greater activity observed with longer chain acyl-CoAs such as myristoyl- and palmitoyl-CoA. THEM2 associates with StarD, a protein that plays a key role in fatty acid metabolism, and the addition of StarD to THEM2 increased its catalytic activity, suggesting that THEM2 plays a significant role in the metabolism of fatty acids.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500070.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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