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SAB3500370 Sigma-Aldrich

Anti-TRBP1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym: Anti-TAR RNA binding protein 1, Anti-TARBP1, Anti-TRP-185, Anti-TRP-1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies with Corresponding Blocking Peptides, Primary Antibodies, T,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   indirect ELISA: suitable
  western blot: suitable
species reactivity   human, mouse
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   100
antibody product type   primary antibodies
NCBI accession no.   NP_005637
UniProt accession no.   Q13395
Gene Information   human ... TARBP1(6894)

Description

General description

The gene TARBP1 (TAR (HIV-1) RNA binding protein 1) is mapped to human chromosome 1q42.2. The protein has dsRBDs (double stranded RNA binding domains), a KR motif in the dsRBD2 and a Medipal domain.

Immunogen

TRBP1 antibody was raised against a 17 amino acid peptide from near the center of human TRBP1.

Physical form

Supplied in PBS with 0.02% sodium azide.

Biochem/physiol Actions

TARBP1 (TAR (HIV-1) RNA binding protein 1) binds strongly to the small hairpin trans-activation responsive (TAR) RNA of HIV (human immunodeficiency virus)-1. It might have a role in disengaging RNA polymerase II from HIV-1 TAR RNA. In addition, it is also a part of the RNA-induced silencing complex (RISC). It interacts with Dicer and helps in processing of pre-microRNAs. TARBP1 also participates in other cellular functions, such as protein synthesis, RNA post-translational modifications, cellular proliferation, gene expression and stress-associated cellular processes.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500370.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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