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SAB4100131 Sigma-Aldrich

Monoclonal Anti-BIRC5 antibody produced in mouse

clone BIRC5-A113, culture supernatant

Synonym: Anti-API4, Anti-Apoptosis inhibitor 4, Anti-Baculoviral IAP repeat-containing 5, Anti-EPR-1, Anti-Survivin variant 3 alpha

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Properties

Related Categories Alphabetical Index, Antibodies, B-BI, Primary Antibodies
species reactivity   human
application(s)   western blot: suitable
clone   BIRC5-A113, monoclonal
antibody form   culture supernatant
form   aqueous solution
isotype   IgG1
mol wt   antigen predicted mol wt 16.2 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... BIRC5(332)
biological source   mouse
antibody product type   primary antibodies
conjugate   unconjugated
UniProt accession no.   O15392

Description

Immunogen

BIRC5 purified recombinant protein

General description

BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5), also known as Survivin, is a transmembrane glycoprotein receptor encoded by the BIRC5 gene in humans. It consists of a unique cysteine-rich extracellular module, a single membrane-spanning domain, and a serine-rich (26%) cytoplasmic tail with at least 15 potential phosphorylation sites.

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Monoclonal Anti-BIRC5 antibody produced in mouse is suitable for western blot application.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

BIRC5 (Baculoviral inhibitor of apoptosis repeat-containing 5) functions as a cell surface receptor for factor Xa. It is predicted to be a potential factor in protease-dependent cellular effector functions. It also behaves as a receptor for factor Xa during the cell surface assembly of proteolytic activities and leukocyte mitogenesis. A study reports that the expression of BIRC5 can be controlled by mRNA splicing. It is an inhibitor of apoptosis and is expressed in various malignancies.

Safety & Documentation

Documents

Certificate of Analysis

Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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