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  • SAB4200016 - Anti-SLC9A1 antibody produced in rabbit

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SAB4200016 Sigma-Aldrich

Anti-SLC9A1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-APNH, Anti-NHE1, Anti-Na-Li counter transporter, Anti-Porter, Sodium-hydrogen ion, amiloride-sensitive, Anti-Sodium/hydrogen exchanger 1, Anti-Solute carrier family 9, Isoform A1, Anti-Solute carrier family 9, member 1

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Drug Transport Proteins, Antibodies to Ion Channels,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 2.5-5.0 μg/mL using whole extract of human platelets
species reactivity   human
mol wt   antigen ~95 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
concentration   ~1.0 mg/mL
UniProt accession no.   P19634
Gene Information   human ... SLC9A1(6548)

Description

General description

The solute carrier family 9 member A1 (SLC9A1) gene is mapped to human chromosome 1p36.11. The encoded protein is widely expressed in many tissues and is localized to the plasma membrane. SLC9A1 is the only isoform found in mammalian cardiomyocytes. This gene encodes a 815 amino acid protein containing 12 transmembrane spanning domain and a cytoplasmic domain with many regulatory sites.

Application

Anti-SLC9A1 antibody produced in rabbit has been used in western blotting.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Solute carrier family 9 member A1 (SLC9A1) mediates the electroneutral exchange of Na+-H+ in response to intracellular acidosis. It drives extracellular Na+ uptake in exchange for intracellular H+. SLC9A1 maintains the pH and cell volume regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters and cell shrinkage.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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