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  • SAB4200073 - Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit

SAB4200073 Sigma-Aldrich

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

Synonym: Anti-C polypeptide, protein-glutamine-gamma-glutamyltransferase, Anti-G-alpha-h, Anti-TG2, Anti-TGC, Anti-TGM2

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Other Apoptosis-related Proteins,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: 5-10 μg/mL using formalin-fixed and paraffin embedded human placenta
  immunoprecipitation (IP): 15-30 μg using human placenta extracts
  indirect immunofluorescence: 2-4 μg/mL using U87 cells
  western blot: 1-2 μg/mL using U87 cell extracts
species reactivity   human
mol wt   antigen ~78 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
packaging   antibody small pack of 25 μL
antibody form   affinity isolated antibody
antibody product type   primary antibodies
concentration   ~1.5 mg/mL
UniProt accession no.   Q07283
Gene Information   human ... TCHH(7052)


General description

Tranglutaminase-2 (also known as TGM2, TG2), is a widely expressed, multifunctional protein.


Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit has been used in:
•  immunoblotting
• immunoprecipitation
•  immunofluorescence
• immunohistochemistry

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Tranglutaminase-2 possesses enzymatic and GTPase activities, involved in multiple cell functions, including cell adhesion and cell signaling. TGM2 functions as a Ca2+-dependent enzyme capable of crosslinking both cytosolic and extracellular matrix proteins by catalyzing the formation of isopeptide bonds between lysine and glutamine residues. TGM2 is involved in the regulation of cell-matrix adhesion, cytoskeletal structure, cell migration and apoptosis. It is activated in response to tissue injury and plays an important role in wound healing and immune response. TGM2 is a major autoantigen in celiac disease and altered TGM2 expression or activity may be associated with Alzheimer′s disease, arteriosclerosis, type-2 diabetes and cancer metastasis in numerous forms of cancer.

Safety & Documentation

Safety Information

NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


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