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  • SAB4200161 - Anti-Tensin 2 antibody produced in rabbit

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SAB4200161 Sigma-Aldrich

Anti-Tensin 2 antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody

Synonym: Anti-C1TEN, Anti-TENC1, Anti-TNS2

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   western blot: 0.5-1.0 μg/mL using HEK-293T cell lysates overexpressing human tensin 2
species reactivity   rat, human, mouse
mol wt   antigen ~160 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
concentration   ~0.5 mg/mL
Gene Information   human ... TENC1(23371)
mouse ... Tenc1(209039)
rat ... Tenc1(315326)

Description

General description

Tensins are a family of focal adhesion proteins that link the extracellular matrix (ECM) and the cytoskeleton via integrins. The tensin family includes four members: tensin 1-4, encoded by different genes. Tensin proteins consists of homologous C1, protein tyrosine phosphatase (PTPase), C2, SH2 and phosphotyrosine-binding domain (PTB) domains. Tensin 2 is very similar to tensin1 at its N- and C-terminus. They have similar actin binding domain, SH2 and PTB domains. Tensin 2 is a binding partner for Axl receptor tyrosine kinase. Tensin 2 mRNA is highly expressed in heart, liver, kidney and skeletal muscle.

Application

Anti-Tensin 2 antibody produced in rabbit has been used in immunoblotting.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Tensins play an important role in regulating cell shape and motility. Abnormal expression of tensins are implicated in various forms of human cancers. Expression of tensin 2 and tensin 3 are markedly reduced in a panel of diverse human cancer cell lines and all four genes are downregulated in human kidney cancer. Tensin 2 induces growth inhibition and apoptosis in hepatocellular carcinoma (HCC) cell lines. Tensin 2 interacts directly with deleted in liver cancer 1 (DLC1), a tumor suppressor protein often deleted and downregulated in HCC cell lines and other types of cancers. Tensin 2 may be important for normal kidney function in vivo.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Protocols

Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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Peer-Reviewed Papers
15

References

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