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  • SAB4200178 - Anti-Importin 5 (N-terminal) antibody produced in rabbit

SAB4200178 Sigma

Anti-Importin 5 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym: Anti-IPO5, Anti-KPNB3, Anti-importin subunit beta-3, Anti-karyopherin beta-3



Related Categories Alphabetical Index, Antibodies, Antibodies to Nuclear Proteins, Epigenetics, IH-IM,
species reactivity   human
application(s)   immunoprecipitation (IP): 5-10 μg using lysates of human HEK-293T cells.
  indirect immunofluorescence: 2.5-5.0 μg/mL using HEK-293T cells overexpressing human Importin 5.
  western blot: 2-4 μg/mL using whole extracts of human Jurkat cells.
clone   polyclonal
concentration   ~1.0 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~123 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... IPO5(3843)
biological source   rabbit
conjugate   unconjugated



synthetic peptide corresponding to amino acids 49-62 of human Importin 5 conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat Importin 5.

General description

Importin 5 (IPO5) is encoded by the gene mapped to human chromosome 13q32.2. The encoded protein belongs to the importin β family. It is primarily expressed in cytoplasm, specifically in the nuclear pore complex.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.


Anti-Importin 5 (N-terminal) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Importin 5 (IPO5) in association with nucleoside triphosphates and the small GTP binding protein Ran, facilitates migration of nuclear localization signal (NLS)-containing cargo from cytoplasm to nucleus. IPO5 also plays a vital role in apolipoprotein A-1 excretion and also helps in transport of lipids from peripheral tissues via reverse cholesterol transport pathway. Additionally, the encoded protein facilitates transport of ribosomal proteins and core histones into the nucleus. Mutation in the gene is associated with the development of schizophrenia.

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