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  • SAB4200203 - Monoclonal Anti-RAVER1 antibody produced in mouse

SAB4200203 Sigma-Aldrich

Monoclonal Anti-RAVER1 antibody produced in mouse

~1.0 mg/mL, clone RAV1, purified immunoglobulin

Synonym: Anti-Ribonucleoprotein PTB-binding 1

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Adhesion Molecules and Related Proteins, Antibodies to Cell and Organelle Proteins,
conjugate   unconjugated
clone   RAV1, monoclonal
biological source   mouse
application(s)   immunoprecipitation (IP): suitable
  western blot (chemiluminescent): 1.0-2.0 μg/mL using HeLa or HepG2 cells extract
species reactivity   monkey, human
mol wt   antigen ~80 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   purified immunoglobulin
isotype   IgG1
antibody product type   primary antibodies
concentration   ~1.0 mg/mL
UniProt accession no.   Q8IY67
Gene Information   human ... RAVER1(125950)


General description

Monoclonal Anti-RAVER1 (mouse IgG1 isotype) is derived from the hybridoma RAV1 produced by the fusion of mouse myeloma cells (NS1) and splenocytes from mouse immunized with a peptide corresponding to a fragment of human RAVER1. Raver1, also known as ribonucleoprotein PTB-binding 1, is a widely expressed multidomain protein, identified in two-hybrid screens by its ability to interact and colocalize with the cytoskeletal proteins -actinin and vinculin. The protein is composed of three RNA recognition motifs (RRM) and of nuclear localization and nuclear export signals, allowing it to shuttle between the nucleus and the cytoplasm. Raver1 also colocalizes with PTB/hnRNPI.


Monoclonal Anti-RAVER1 antibody produced in mouse has been used in immunoblotting.

Physical form

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

RAVER1 (ribonucleoprotein, PTB binding 1) is involved in RNA splicing of microfilament proteins. In skeletal muscle, a translocation of Raver1 from the nucleus to the cytoplasm is correlated with the differentiation of specific microfilament attachment sites. Based on an analysis of Vinculin-Raver1 crystal structure it was suggested that vinculin recruits raver1 and its mRNAs cargo to focal adhesions, promoting localization of the synthesis of adhesion complexes by the translational machinery.

Safety & Documentation

Safety Information

NONH for all modes of transport
Protocols & Articles


Antibody Basics

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