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  • SAB4200438 - Anti-EXOSC5 (C-terminal) antibody produced in rabbit

SAB4200438 Sigma-Aldrich

Anti-EXOSC5 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym: Anti-Exosome component 5, p12B, Anti-RRP41B, Anti-RRP46, Anti-Rrp46p, Anti-hRrp46p

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, Cell Biology, Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunoprecipitation (IP): 1-2 μg using lysates of human HeLa cells.
  indirect immunofluorescence: 5-10 μg/mL using human HeLa cells.
  western blot: 1-2 μg/mL using whole extracts of human HEK-293T cells.
species reactivity   human
mol wt   antigen ~25 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
Quality Level   200
antibody product type   primary antibodies
concentration   ~1.0 mg/mL
UniProt accession no.   Q9NQT4
Gene Information   human ... EXOSC5(56915)
mouse ... Exosc5(27998)
rat ... Exosc5(308441)


General description

Exosome component 5 (EXOSC5) protein is a component of the eukaryotic RNA exosome complex and is non-catalytic. The EXOSC5 gene is mapped on the human chromosome at 19q13.2.


Anti-EXOSC5 (C-terminal) recognizes human EXOSC5(not tested in other species).


synthetic peptide corresponding to the C-terminal region of human EXOSC5, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine, dog and pig.


Anti-EXOSC5 (C-terminal) antibody produced in rabbit may be used in:
• immunoblotting
• immunofluorescence
• immunoprecipitation

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

Exosome component 5 (EXOSC5) protein exhibits 3′-5′ exoribonuclease activity. This protein is involved in RNA processing and RNA degradation episode. EXOSC5 protein is also involved in cleaving the DNA during apoptosis. Overexpression of the EXOSC5 gene is associated with melanoma, prostate, colorectal and lung cancer.

Safety & Documentation

Safety Information

NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy


Western Blot Protocol | Immunoblotting Protocol

Western Blotting refers to the electrophoretic transfer of proteins from sodium dodecyl sulfate polyacrylamide gels to sheets of PVDF or nitrocellullose membrane, followed by immunodetection of prote...
Keywords: AGE, Buffers, Cell disruption, Detection methods, Detergents, Dialysis, Electroblotting, Electrophoresis, Enzyme activity, Gel electrophoresis, Immunoprecipitation, PAGE, Protein extraction, Purification, Sample preparations, Western blot

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