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SAB4200493 Sigma-Aldrich

Anti-IAPP antibody produced in rabbit

Antibody Enhanced Validation

~1.0 mg/mL, affinity isolated antibody

Synonym: Anti-Diabetes-associated peptide, Anti-Amylin, Anti-DAP, Anti-IAP, Anti-Islet amyloid polypeptide

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Transforming Growth Factor-beta (TGF-beta) and Superfamily,
conjugate   unconjugated
clone   polyclonal
biological source   rabbit
application(s)   immunohistochemistry: 5-10 μg/mL using formalin-fixed paraffin-embedded human pancreas.
  indirect immunofluorescence: 1-2 μg/mL using rat insulinoma RIN-5F cells.
species reactivity   rat, human
enhanced validation   independent ( Antibodies)
Learn more about Antibody Enhanced Validation
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
antibody form   affinity isolated antibody
antibody product type   primary antibodies
concentration   ~1.0 mg/mL
UniProt accession no.   P10997
Gene Information   mouse ... Iapp(15874)
rat ... Iapp(24476)

Description

General description

Islet amyloid polypeptide (IAPP, amylin), is a 37-residue peptide hormone co-secreted with insulin from the pancreatic β-cells. IAPP is processed from an 89-amino acid precursor pro-islet amyloid polypeptide (proIAPP) in pancreatic β-cells that undergoes complex posttranslational modifications including protease cleavage, C-terminal amidation and formation of an intramolecular disulfide bridge to produce the mature IAPP.

Immunogen

synthetic peptide corresponding to a sequence at the C-terminus of rat pro-IAPP, conjugated to KLH. The corresponding sequence is identical in mouse IAPP and has 74% sequence identity with human IAPP.

Application

Anti-IAPP antibody produced in rabbit has been used in immunohistochemistry and immunofluorescence.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biochem/physiol Actions

IAPP/Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels. IAPP has been linked to type 2 diabetes (T2DM) and the loss of islet b-cells. The human IAPP (20-29) region that has been found to be essential to amyloid formation is thought to be a key factor in the initiation of amyloid aggregation. Islet amyloid formation, initiated by the aggregation of IAPP, may contribute to this progressive loss of islet β-cells. Amyloid deposits deriving from IAPP are commonly found in pancreatic islets of patients suffering of T2DM, or containing an insulinoma cancer. IAPP, like β-amyloid peptide associated with Alzheimer′s disease, can induce apoptosis in insulin producing β-cells.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
Protocols & Articles

Articles

Antibody Basics

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Peer-Reviewed Papers
15

References

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