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SAB4200759 Sigma-Aldrich

Anti-Human IgG3 antibody, Mouse monoclonal

clone HP-6050, purified from hybridoma cell culture

Synonym: Anti-Immunoglobulin G3

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Properties

Quality Level   200
biological source   mouse
antibody product type   primary antibodies
clone   HP-6050, monoclonal
form   buffered aqueous solution
species reactivity   human
concentration   ~1.0 mg/mL
application(s)   immunoprecipitation (IP): 1-2.5 μg/test using Human IgG3 myeloma
  indirect ELISA: 0.15-0.3 μg/mL using 1 μg/ml Human IgG3 myeloma for coating
isotype   IgG1
shipped in   dry ice
storage temp.   −20°C

Description

General description

Human IgG consist of four subclasses (1-4) that can be recognized by antigenic differences in their heavy chains. They constitute approximately 65, 30, 5 and 4% of the total IgG, respectively. The abundance of the different IgG subclasses in the bloodstream varies with age, IgG1 and IgG3 reach normal adult levels by 5-7 years of age while IgG2 and IgG4 levels rise more slowly, reaching adult levels at about 10 years of age.

Immunogen

Human IgG3 myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads

Application

Anti-Human IgG3 antibody, mouse monoclonal has been used in indirect ELISA and immunoprecipitation.

Biochem/physiol Actions

IgG1 and IgG3 are the only subclasses capable of adherence to mononuclear phagocytes and are recognized readily by the Fc receptors on various reticulo-endothelial . IgG3 deficiency has been associated with a history of recurrent infectious, leading to chronic lung disease.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Protocols & Articles
Peer-Reviewed Papers
15

References

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