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SAB4200771 Sigma-Aldrich

Anti-Surfactant Protein D antibody, Mouse monoclonal

clone 10F6E12, purified from hybridoma cell culture

Synonym: Anti-Collectin-7, Anti-Lung surfactant protein D, Anti-PSP-D, Anti-Pulmonary surfactant-associated protein D, Anti-SP-D

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Properties

clone   10F6E12, monoclonal
biological source   mouse
application(s)   immunoblotting: 2-4 μg/mL using mouse lung extract
species reactivity   human, mouse
mol wt   ~43 kDa
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
isotype   IgG1
Quality Level   200
antibody product type   primary antibodies
concentration   ~1 mg/mL
UniProt accession no.   P35247
Gene Information   human ... Sftpd(20390)

Description

General description

Surfactant Protein D (SFTPD) belongs to the collectin family of multimeric glycoproteins and exists as oligomeric structure or a trimeric subunit. The human SFTPD corresponds to a molecular weight of 150kDa and the trimer is close to 620 kDa. Anti-Surfactant Protein D antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the 10F6E12 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with mouse recombinant SP-D.

Surfactant Protein D (SP-D) contains an N-terminal cysteine-rich domain, a collagenous domain, a neck region and a C-terminal carbohydrate recognition domain (CRD). The gene is located on human chromosome 14. SP-D is expressed in lungs and kidney.

Immunogen

Mouse recombinant SP-D

Application

Anti-Surfactant Protein D antibody, Mouse monoclonal may be used in immunoblotting.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Biochem/physiol Actions

Surfactant Protein D (SFTPD) imparts pulmonary defense during fungal infection. It favors pulmonary inflammation. It recognizes the surface lipopolysaccharide (LPS) of pathogens and acts as first-line host defense molecule. It also recognizes the viral glycoprotein hemagglutinin (HA) present in viral surface. Polymorphism in the SFTPD gene may lead to decreased levels of the protein and high risk for chronic obstructive pulmonary disease (COPD).

Surfactant Protein D (SP-D) plays a critical role in the innate host defense and the modulation of inflammatory responses in infectious diseases. It aids the uptake and clearance of pathogens and apoptotic cells. SP-D maintains surfactant homeostasis. It reduces the surface tension at the air-liquid interface and blocks the lung from collapsing.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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